Yes. As far as I can tell on my PC. But not all computers may support this feature depending on the usb port and Bios settings. Its Newer PC vs Older PC architecture.
How to Find Out Where Your PC StandsYou can quickly diagnose your computer's era right now:Open your Windows Start menu, type cmd, and hit Enter.Type powercfg /a and press Enter.If it says "Network Connectivity in Standby (S0 Low Power Idle)" is supported, your PC is a modern architecture system. Wake-on-LAN through a simple USB dongle will be very difficult to stabilize without a specialized powered hub.If it lists Traditional Sleep (S3), your PC is configured with the classic architecture, and getting the TP-Link UE300 to work should be straightforward.